3-Chloro-5-methylbenzaldehyde

Name: 3-Chloro-5-methylbenzaldehyde
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 103426-20-6
Cat. No. CS-0061256
Purity≥95%
MDL No.MFCD11553565

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Chloro-5-methylbenzaldehyde|CS-0061256

Structure of 103426-20-6

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General Information

CAS No. 103426-20-6
Cat. No. CS-0061256
Purity ≥95%
MDL No. MFCD11553565
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇ClO
Molecular Weight None
Synonym(s) 3-chloro-5-methyl-benzaldehyde
SMILES CC1=CC(=CC(=C1)Cl)C=O

Description

3-Chloro-5-methylbenzaldehyde features a benzaldehyde core with electron-withdrawing chlorine and electron-donating methyl groups in meta and para positions relative to the aldehyde. This substitution pattern imparts enhanced reactivity in nucleophilic addition reactions while maintaining bench-stable handling characteristics. The compound serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and functionalized heterocycles.

Application

3-Chloro-5-methylbenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted aromatic scaffolds. Its ortho-chloro and meta-methyl substituents provide predictable electronic and steric modulation, enhancing reactivity in nucleophilic additions, Grignard couplings, and Ullmann-type transformations. The aldehyde functionality offers high compatibility with standard functional group manipulations, including reductive amination and Wittig reactions. Bench-stable and readily purified by distillation or recrystallization, it supports scalable synthesis workflows with consistent yields across diverse reaction conditions.

Synthesis

Route1
- 62358-81-0
- ~41%
- In-stock
  
  103426-20-6
References
- WO2007/25307 A2, ; Page/Page column 307 ; WO 2007/025307 A2
Route2
- In-stock
  
  189161-09-9
- ~66%
- In-stock
  
  103426-20-6
References
- Journal of the American Chemical Society, , vol. 132, # 33 p. 11389 - 11391

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 17.07
LogP 2.46092
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-Chloro-5-methylbenzaldehyde

CAS No. 103426-20-6

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