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CS-W001157 4
Total: USD 88.00

2-Bromo-4-chloro-5-fluoropyridine

  • CAS No. 1033203-44-9

  • Cat. No. CS-0146033
  • Purity≥95%
  • MDL No.MFCD11100658

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-chloro-5-fluoropyridine|CS-0146033

Structure of 1033203-44-9

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General Information

  • CAS No. 1033203-44-9
  • Cat. No. CS-0146033
  • Purity ≥95%
  • MDL No. MFCD11100658
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrClFN
  • Molecular Weight 210.43
  • Synonym(s) None
  • SMILES FC1=CN=C(Br)C=C1Cl

Description

2-Bromo-4-chloro-5-fluoropyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and fluoro substituents. This combination imparts enhanced reactivity in cross-coupling processes while maintaining stability under standard conditions. The electron-deficient ring system facilitates nucleophilic substitution and enables efficient integration into pharmaceutical intermediates and advanced functional materials.

Application

2-Bromo-4-chloro-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The strategic placement of bromo, chloro, and fluoro substituents allows for sequential functionalization under controlled conditions. Its bench-stable nature and compatibility with standard reaction protocols make it well-suited for the synthesis of complex heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.6366
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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