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CS-W001157 4
Total: USD 88.00

4-Benzylmorpholine

  • CAS No. 10316-00-4

  • Cat. No. CS-W022084
  • Purity≥97%
  • MDL No.MFCD00090503

*For research and further manufacturing use only, not for direct human use.

4-Benzylmorpholine|CS-W022084

Structure of 10316-00-4

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General Information

  • CAS No. 10316-00-4
  • Cat. No. CS-W022084
  • Purity ≥97%
  • MDL No. MFCD00090503
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO
  • Molecular Weight 177.24
  • Synonym(s) N-benzyl-morpholine
  • SMILES N1(CC2=CC=CC=C2)CCOCC1

Description

4-Benzylmorpholine features a morpholine core substituted at the 4-position with a benzyl group, delivering enhanced lipophilicity and metabolic stability. This structural motif integrates readily into bioactive molecules, serving as a key scaffold in medicinal chemistry for modulating pharmacokinetic properties and target engagement.

Application

4-Benzylmorpholine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization protocols. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient synthesis of pharmaceutical intermediates. The benzyl group enhances lipophilicity and metabolic stability, while the morpholine core provides a tunable nitrogen handle for further derivatization.

Synthesis

  • Route1
    • null|null
      110-91-8
    • null|null
      100-39-0
    • ~99%
    • In-stock
      4-Benzylmorpholine|CS-W022084
      10316-00-4

    References

    • Rattanaburi, Parintip; Khumraksa, Bannarak; Pattarawarapan, Mookda Tetrahedron Letters, 2012 , vol. 53, # 22 p. 2689 - 2693
  • Route2
    • null|null
      110-91-8
    • null|null
      100-52-7
    • ~97%
    • In-stock
      4-Benzylmorpholine|CS-W022084
      10316-00-4

    References

    • Alinezhad, Heshmatollah; Tajbakhsh, Mahmood; Hamidi, Neda Chinese Chemical Letters, 2010 , vol. 21, # 1 p. 47 - 50
  • Route3
    • null|null
      110-91-8
    • In-stock
      Benzyl alcohol|CS-4355
      100-51-6
    • ~87%
    • In-stock
      4-Benzylmorpholine|CS-W022084
      10316-00-4

    References

    • Cui, Xinjiang; Dai, Xingchao; Deng, Youquan; Shi, Feng Chemistry - A European Journal, 2013 , vol. 19, # 11 p. 3665 - 3675

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   1.5188
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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