1-(Tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Name: 1-(Tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1029715-63-6
Cat. No. CS-W020669
Purity≥95%
MDL No.MFCD18383269

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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1-(Tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-W020669

Structure of 1029715-63-6

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General Information

CAS No. 1029715-63-6
Cat. No. CS-W020669
Purity ≥95%
MDL No. MFCD18383269
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₁BN₂O₃
Molecular Weight 264.13
Synonym(s) 1-Tetrahydrofuran-3-yl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole
SMILES CC1(C)C(C)(C)OB(C2=CN(C3COCC3)N=C2)O1

Description

This pyrazole derivative features a tetrahydrofuran-3-yl group paired with a boronate ester, enabling efficient cross-coupling under standard conditions. The dioxaborolane moiety delivers stability and reactivity in Suzuki-Miyaura transformations, while the heterocyclic core provides a rigid scaffold for medicinal chemistry applications.

Application

1-(Tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetrahydrofuran-3-yl group provides steric and electronic modulation, while the pinacol boronate moiety ensures excellent stability, ease of handling, and compatibility with diverse reaction conditions. This reagent enables efficient construction of functionalized pyrazole scaffolds in medicinal chemistry and materials science workflows.

Synthesis

Route1
- In-stock
  
  1040377-07-8
- In-stock
  
  73183-34-3
- ~67%
- In-stock
  
  1029715-63-6
References
- XCOVERY, INC. Patent: WO2008/88881 A1, 2008 ; Location in patent: Page/Page column 46 ; WO 2008/088881 A1
Route2
- In-stock
  
  269410-08-4
- 156380-34-6
- ~%
- In-stock
  
  1029715-63-6
References
- INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing Patent: WO2010/75270 A1, 2010 ; Location in patent: Page/Page column 164 ; WO 2010/075270 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 45.51
LogP 1.1437
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-(Tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

CAS No. 1029715-63-6

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