3-bromo-5-chloro-2-methoxypyridine

Name: 3-bromo-5-chloro-2-methoxypyridine
Brand: ChemScene
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CAS No. 102830-75-1
Cat. No. CS-W000828
Purity≥98%
MDL No.MFCD08059322

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-bromo-5-chloro-2-methoxypyridine|CS-W000828

Structure of 102830-75-1

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General Information

CAS No. 102830-75-1
Cat. No. CS-W000828
Purity ≥98%
MDL No. MFCD08059322
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrClNO
Molecular Weight 222.47
Synonym(s) 2-Methoxy-3-Bromo-5-Chloropyridine
SMILES COc1ncc(Cl)cc1Br

Description

3-Bromo-5-chloro-2-methoxypyridine features a halogenated pyridine core with complementary reactive sites for cross-coupling and functionalization. The methoxy group enhances solubility and modulates electronic properties, while the ortho-bromine enables palladium-catalyzed transformations. This compound serves as a key building block in pharmaceutical synthesis and agrochemical development under standard conditions.

Application

3-Bromo-5-chloro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient Suzuki, Stille, or Negishi coupling, while the chloro and methoxy substituents provide tunable electronic and steric profiles. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Synthesis

Route1
- In-stock
  
  13473-01-3
- ~72%
- In-stock
  
  102830-75-1
References
- Journal of Heterocyclic Chemistry, , vol. 22, p. 1583 - 1592
Route2
- In-stock
  
  16110-09-1
- ~%
- In-stock
  
  102830-75-1
References
- Journal of Heterocyclic Chemistry, , vol. 22, p. 1583 - 1592

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 22.12
LogP 2.5061
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-bromo-5-chloro-2-methoxypyridine

CAS No. 102830-75-1

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