4-Chloro-5-iodo-2-(trifluoromethyl)pyridine

Name: 4-Chloro-5-iodo-2-(trifluoromethyl)pyridine
Brand: ChemScene
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CAS No. 1027818-88-7
Cat. No. CS-0157806
Purity≥97%
MDL No.MFCD24369746

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Chloro-5-iodo-2-(trifluoromethyl)pyridine|CS-0157806

Structure of 1027818-88-7

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General Information

CAS No. 1027818-88-7
Cat. No. CS-0157806
Purity ≥97%
MDL No. MFCD24369746
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClF₃IN
Molecular Weight 307.44
Synonym(s) 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline
SMILES C1=C(C(=CN=C1C(F)(F)F)I)Cl

Description

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine features a trifluoromethyl group flanked by chlorine and iodine substituents on a pyridine core, enabling selective cross-coupling reactions. The electron-deficient aromatic framework supports palladium-catalyzed transformations, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity in medicinal chemistry applications.

Application

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine serves as a versatile heterocyclic building block for Suzuki-Miyaura and Sonogashira coupling reactions, enabling efficient construction of biaryl and alkynyl scaffolds. The orthogonal reactivity of the chloro and iodo substituents allows sequential functionalization under mild conditions. Bench-stable and compatible with diverse reaction environments, it facilitates the synthesis of complex trifluoromethylated pyridine derivatives relevant to pharmaceutical and agrochemical development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 12.89
LogP 3.3584
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-5-iodo-2-(trifluoromethyl)pyridine

CAS No. 1027818-88-7

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