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CS-W001157 4
Total: USD 88.00

m-PEG1-NHS ester

  • CAS No. 1027371-75-0

  • Cat. No. CS-0063348
  • Purity≥95%
  • MDL No.MFCD20229579

*For research and further manufacturing use only, not for direct human use.

m-PEG1-NHS ester|CS-0063348

Structure of 1027371-75-0

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General Information

  • CAS No. 1027371-75-0
  • Cat. No. CS-0063348
  • Purity ≥95%
  • MDL No. MFCD20229579
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO₅
  • Molecular Weight 201.18
  • Synonym(s) None
  • SMILES COCCC(ON1C(CCC1=O)=O)=O

Description

m-PEG1-NHS ester enables efficient conjugation of biomolecules under physiological conditions. This water-soluble linker features a reactive NHS ester group that selectively couples with primary amines, offering rapid labeling and minimal hydrolysis. Ideal for antibody-drug conjugates and protein modifications.

Application

m-PEG1-NHS ester serves as a versatile, bench-stable coupling reagent for amine-functionalized molecules, enabling efficient conjugation under physiological conditions. Its short PEG spacer enhances solubility and reduces steric hindrance, while the NHS ester group facilitates rapid reaction with primary amines. Ideal for bioconjugation workflows, it supports high yields and straightforward purification, making it well-suited for peptide, protein, and oligonucleotide derivatization in drug discovery and diagnostic development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   72.91
  • LogP   -0.3699
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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