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Ethyl 2-(6-chloropyridazin-3-yl)acetate

  • CAS No. 1023817-10-8

  • Cat. No. CS-0055263
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(6-chloropyridazin-3-yl)acetate|CS-0055263

Structure of 1023817-10-8

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General Information

  • CAS No. 1023817-10-8
  • Cat. No. CS-0055263
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClN₂O₂
  • Molecular Weight 200.62
  • Synonym(s) Ethyl 3-chloropyridazine-6-acetate
  • SMILES O=C(OCC)CC1=NN=C(Cl)C=C1

Description

Ethyl 2-(6-chloropyridazin-3-yl)acetate features a chlorinated pyridazine core linked to an ethyl ester-functionalized acetyl side chain. This compound serves as a key intermediate in the synthesis of bioactive heterocycles, particularly within medicinal chemistry programs targeting kinase inhibitors and antiviral agents. The electron-deficient pyridazine ring enhances reactivity in nucleophilic substitution processes, while the ester moiety enables further derivatization via hydrolysis or coupling reactions. Bench-stable under standard conditions, it facilitates efficient incorporation into complex molecular architectures without requiring stringent handling protocols.

Application

Ethyl 2-(6-chloropyridazin-3-yl)acetate serves as a versatile building block for constructing pyridazinone-based heterocycles and bioactive scaffolds. The electrophilic chloro group enables facile nucleophilic substitution, while the ester functionality supports subsequent transformations such as hydrolysis, reduction, or coupling reactions. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for medicinal chemistry campaigns and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P280-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.2356
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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