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CS-W001157 4
Total: USD 88.00

2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid

  • CAS No. 34415-10-6

  • Cat. No. CS-0044230
  • Purity≥96%
  • MDL No.MFCD09910319

*For research and further manufacturing use only, not for direct human use.

2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid|CS-0044230

Structure of 34415-10-6

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General Information

  • CAS No. 34415-10-6
  • Cat. No. CS-0044230
  • Purity ≥96%
  • MDL No. MFCD09910319
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) 2-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid
  • SMILES O=C(C(N=C(C)N1)=CC1=O)O

Description

This dihydropyrimidine derivative features a conjugated carbonyl system and a carboxylic acid group, enabling direct integration into peptide coupling workflows. The methyl substituent enhances stability, while the oxo and carboxylic functionalities provide versatile handles for downstream functionalization in medicinal chemistry applications.

Application

2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds. Its conjugated enone system and carboxylic acid functionality support diverse transformations, including nucleophilic additions, decarboxylative couplings, and cyclizations. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process-scale applications.

Synthesis

  • Route1
    • null|null
      132056-21-4
    • ~%
    • In-stock
      2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid|CS-0044230
      34415-10-6

    References

    • Helvetica Chimica Acta, , vol. 5, p. 278
  • Route2
    • null|null
      124-42-5
    • In-stock
      Diethyl 2-oxobutanedioate|CS-W016821
      108-56-5
    • ~%
    • In-stock
      2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid|CS-0044230
      34415-10-6

    References

    • Chemische Berichte, , vol. 25, p. 1423 Die Imidoaether und ihre Derivate <Berlin 1892>,S.221

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   83.05
  • LogP   -0.22348
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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