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CS-W001157 4
Total: USD 88.00

5-Methyl-3-pyridinemethanol

  • CAS No. 102074-19-1

  • Cat. No. CS-0040539
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD08236816

*For research and further manufacturing use only, not for direct human use.

5-Methyl-3-pyridinemethanol|CS-0040539

Structure of 102074-19-1

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General Information

  • CAS No. 102074-19-1
  • Cat. No. CS-0040539
  • Purity ≥97%
  • MDL No. MFCD08236816
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight None
  • Synonym(s) 3-Pyridinemethanol, 5-methyl-
  • SMILES OCC1=CC(C)=CN=C1

Description

5-Methyl-3-pyridinemethanol features a pyridine ring bearing a methyl group at the 5-position and a primary alcohol at the 3-position, offering a versatile scaffold for medicinal chemistry. The electron-rich aromatic core enables efficient functionalization, while the benzylic alcohol facilitates derivatization under mild conditions. This bench-stable compound integrates readily into complex molecular architectures requiring polar, heteroaromatic motifs with controlled solubility and metabolic stability.

Application

5-Methyl-3-pyridinemethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds. Its benzyl-like reactivity facilitates straightforward functionalization at the methylene group, while the 5-methyl substituent enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with standard coupling and oxidation protocols, making it well-suited for both small-molecule synthesis and API intermediate development.

Synthesis

  • Route1

    References

    • Kemnitzer, William; Drewe, John; Jiang, Songchun; Zhang, Hong; Wang, Yan; Zhao, Jianghong; Jia, Shaojuan; Herich, John; Labreque, Denis; Storer, Richard; Meerovitch, Karen; Bouffard, David; Rej, Rabindra; Denis, Real; Blais, Charles; Lamothe, Serge; Attardo, Giorgio; Gourdeau, Henriette; Tseng, Ben; Kasibhatla, Shailaja; Cai, Sui Xiong Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6299 - 6310
  • Route2

    References

    • Chen, Xi-Bo; Hu, Qiu-Peng; Yuan, Qian-Jia; Ding, Wei; Ren, Jiangmeng; Zeng, Bu-Bing Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3798 - 3801
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 53, # 15 p. 3513 - 3521

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.88232
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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