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CS-W001157 4
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5-Methyl-pyridine-3-carbaldehyde

  • CAS No. 100910-66-5

  • Cat. No. CS-W019763
  • Purity≥96%
  • MDL No.MFCD08272078

*For research and further manufacturing use only, not for direct human use.

5-Methyl-pyridine-3-carbaldehyde|CS-W019763

Structure of 100910-66-5

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General Information

  • CAS No. 100910-66-5
  • Cat. No. CS-W019763
  • Purity ≥96%
  • MDL No. MFCD08272078
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO
  • Molecular Weight 121.14
  • Synonym(s) 5-Methyl-3-pyridinecarboxaldehyde; 3-Formyl-5-methylpyridine; 5-Methylnicotinaldehyde
  • SMILES O=CC1=CC(C)=CN=C1

Description

5-Methyl-pyridine-3-carbaldehyde features a pyridine ring with methyl and aldehyde groups in a 5,3-configuration, delivering enhanced electron-withdrawing character. This arrangement supports efficient coupling in cross-coupling reactions and enables direct incorporation into heterocyclic scaffolds. The compound exhibits favorable solubility in organic solvents and stability under standard handling conditions.

Application

5-Methyl-pyridine-3-carbaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to bioactive heterocycles and pharmaceutical intermediates. Its pyridine core provides favorable electronic properties for metal-catalyzed cross-coupling reactions, while the aldehyde group facilitates condensation, reductive amination, and nucleophilic addition transformations. The methyl substituent enhances solubility and stability, supporting straightforward purification and scalability in process development workflows.

Synthesis

  • Route1

    References

    • Cytovia, Inc. Patent: EP1230232 B1, 2004 ; Location in patent: Page 40 ;
  • Route2

    References

    • French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A. Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
  • Route3
    • null|null
      113118-75-5
    • ~71%
    • In-stock
      5-Methyl-pyridine-3-carbaldehyde|CS-W019763
      100910-66-5

    References

    • Comins, Daniel L.; Herrick, James J. Heterocycles, 1987 , vol. 26, # 8 p. 2159 - 2164

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.20252
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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