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CS-W001157 4
Total: USD 88.00

2-Chloro-4-(chloromethyl)pyridine

  • CAS No. 101990-73-2

  • Cat. No. CS-W003711
  • Purity≥98%
  • MDL No.MFCD09991655

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-(chloromethyl)pyridine|CS-W003711

Structure of 101990-73-2

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General Information

  • CAS No. 101990-73-2
  • Cat. No. CS-W003711
  • Purity ≥98%
  • MDL No. MFCD09991655
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂N
  • Molecular Weight 162.02
  • Synonym(s) Pyridine, 2-chloro-4-(chloromethyl)- (9CI)
  • SMILES ClCc1ccnc(c1)Cl

Description

2-Chloro-4-(chloromethyl)pyridine features a chloromethyl group positioned para to a pyridyl chloride, enabling sequential functionalization in synthetic routes. This dual electrophilic motif supports efficient coupling reactions and integration into complex heterocyclic architectures under mild conditions.

Application

2-Chloro-4-(chloromethyl)pyridine serves as a versatile bifunctional building block in synthetic chemistry, enabling efficient construction of nitrogen-containing heterocycles and pharmaceutical intermediates. The chloromethyl group exhibits high reactivity in nucleophilic substitution reactions, while the 2-chloropyridine moiety provides a robust handle for palladium-catalyzed coupling processes. Its bench-stable nature and compatibility with diverse functional groups facilitate straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • US2009/82329 A1, ; Page/Page column 16 ;
  • Route2

    References

    • WO2006/10642 A1, ; Page/Page column 109 ; WO 2006/010642 A1
  • Route3
    • null|null
      65287-34-5
    • ~43%
    • In-stock
      2-Chloro-4-(chloromethyl)pyridine|CS-W003711
      101990-73-2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 19 p. 5776 - 5780

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.4738
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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