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CS-W001157 4
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7-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid

  • CAS No. 1019021-93-2

  • Cat. No. CS-0041606
  • Purity≥96%
  • MDL No.MFCD09994702

*For research and further manufacturing use only, not for direct human use.

7-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid|CS-0041606

Structure of 1019021-93-2

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General Information

  • CAS No. 1019021-93-2
  • Cat. No. CS-0041606
  • Purity ≥96%
  • MDL No. MFCD09994702
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) CHEMMAKER CMFS-00751
  • SMILES O=C(C1=CN=C2C=C(Br)C=CN21)O

Description

7-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid features a fused heterocyclic core with a bromine substituent at the 7-position and a carboxylic acid group at the 3-position. This combination imparts enhanced reactivity for cross-coupling and derivatization, enabling direct incorporation into bioactive scaffolds. The molecule exhibits excellent stability under standard bench conditions and facilitates efficient functionalization in medicinal chemistry campaigns.

Application

7-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid facilitates amide bond formation and derivatization. The molecule exhibits good bench stability and compatibility with standard synthetic protocols, making it suitable for medicinal chemistry campaigns and process development in API synthesis.

Synthesis

  • Route1

    References

    • WO2011/79076 A1, ; Page/Page column 67 ;
  • Route2

    References

    • WO2011/79076 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.6
  • LogP   1.795
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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