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CS-W001157 4
Total: USD 88.00

1,6-Naphthyridine-3-carboxylic acid

  • CAS No. 1017793-59-7

  • Cat. No. CS-0216897
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,6-Naphthyridine-3-carboxylic acid|CS-0216897

Structure of 1017793-59-7

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General Information

  • CAS No. 1017793-59-7
  • Cat. No. CS-0216897
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆N₂O₂
  • Molecular Weight 174.16
  • Synonym(s) 3-Carboxy-1,6-naphthyridine
  • SMILES C1=CN=CC2=CC(=CN=C12)C(=O)O

Description

1,6-Naphthyridine-3-carboxylic acid features a fused bicyclic core with strategically positioned nitrogen atoms and a carboxylic acid group, enabling robust coordination in metal-ligand frameworks. This electron-deficient heterocycle integrates readily into functionalized molecular architectures, offering enhanced stability and tailored solubility for applications in catalysis and materials science.

Application

1,6-Naphthyridine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and electrophilic substitution reactions. Its rigid fused ring system provides enhanced metabolic stability, while the carboxylic acid functionality facilitates straightforward derivatization and purification. The compound exhibits good bench stability and functional group tolerance, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      250674-52-3
    • ~%
    • In-stock
      1,6-Naphthyridine-3-carboxylic acid|CS-0216897
      1017793-59-7

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2583 - 2586
  • Route2
    • 4-Oxo-1,4-dihydro-[1,6]naphthyridine-3-carboxylic acid ethyl ester|CS-0070360
      92310-23-1
    • ~%
    • In-stock
      1,6-Naphthyridine-3-carboxylic acid|CS-0216897
      1017793-59-7

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2583 - 2586
  • Route3
    • Ethyl 4-chloro-1,6-naphthyridine-3-carboxylate|CS-0462083
      92972-76-4
    • ~%
    • In-stock
      1,6-Naphthyridine-3-carboxylic acid|CS-0216897
      1017793-59-7

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2583 - 2586

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.328
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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