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CS-W001157 4
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tert-Butyl (4,6-dichloropyridin-2-yl)carbamate

  • CAS No. 1017789-38-6

  • Cat. No. CS-0154420
  • Purity≥97%
  • MDL No.MFCD09991634

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (4,6-dichloropyridin-2-yl)carbamate|CS-0154420

Structure of 1017789-38-6

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General Information

  • CAS No. 1017789-38-6
  • Cat. No. CS-0154420
  • Purity ≥97%
  • MDL No. MFCD09991634
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂Cl₂N₂O₂
  • Molecular Weight 263.12
  • Synonym(s) Carbamic acid, N-(4,6-dichloro-2-pyridinyl)-, 1,1-dimethylethyl ester
  • SMILES CC(C)(OC(NC1=CC(Cl)=CC(Cl)=N1)=O)C

Description

tert-Butyl (4,6-dichloropyridin-2-yl)carbamate features a pyridine core with strategic chlorine substitutions at the 4- and 6-positions, enhancing electrophilic reactivity. The tert-butoxycarbonyl group provides stable protection for primary amines, enabling efficient incorporation into complex molecular architectures under standard conditions.

Application

tert-Butyl (4,6-dichloropyridin-2-yl)carbamate serves as a robust protecting group for primary amines in pyridine-based scaffolds, enabling selective functionalization at the 2-position. Its stability under diverse reaction conditions facilitates sequential coupling and derivatization workflows. The dichloro substitution pattern enhances electrophilicity for palladium-catalyzed cross-coupling reactions, making it a versatile building block in medicinal chemistry synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.22
  • LogP   3.7354
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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