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Structure of 1016636-76-2
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6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one features a sterically encumbered pyrido[2,3-d]pyrimidinone core with strategically positioned halogen and alkyl substituents. This configuration enables selective incorporation into kinase inhibitor scaffolds and other bioactive heterocycles under standard coupling conditions.
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one serves as a versatile heterocyclic building block for medicinal chemistry campaigns. Its bromo and chloro substituents enable palladium-catalyzed cross-coupling reactions, while the pyrimidinone core provides a rigid scaffold suitable for targeted ligand design. The cyclopentyl and methyl groups offer favorable steric and lipophilic profiles, enhancing membrane permeability and metabolic stability in drug-like molecules. This compound exhibits bench stability and facilitates straightforward purification via crystallization or flash chromatography.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: