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CS-W001157 4
Total: USD 88.00

3-Methoxybenzensulfonyl chloride

  • CAS No. 10130-74-2

  • Cat. No. CS-0034898
  • Purity≥97%
  • MDL No.MFCD01318155

*For research and further manufacturing use only, not for direct human use.

3-Methoxybenzensulfonyl chloride|CS-0034898

Structure of 10130-74-2

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General Information

  • CAS No. 10130-74-2
  • Cat. No. CS-0034898
  • Purity ≥97%
  • MDL No. MFCD01318155
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClO₃S
  • Molecular Weight 206.65
  • Synonym(s) 3-(Methyloxy)benzenesulfonyl chloride; 3-Methoxybenzene-1-sulfonyl chloride; 3-Methoxybenzensulfonyl chloride; 3-Methoxybenzenesulfonyl chloride
  • SMILES O=S(C1=CC=CC(OC)=C1)(Cl)=O

Description

3-Methoxybenzenesulfonyl chloride may be used to synthesize 3-(4-phenylpiperazin-1yl) sulfonyls and N-(1-(4-methoxybenzyl)-3-cyclopropyl-1Hpyrazol-5-yl)-3-methoxybenzenesulfonamide.

Application

3-Methoxybenzensulfonyl chloride serves as a reliable sulfonylating agent for the synthesis of sulfonamide derivatives and sulfonate esters. Its methoxy substituent enhances electrophilicity while maintaining bench stability and compatibility with common functional groups. The reagent facilitates efficient amide bond formation under mild conditions, enabling straightforward purification and broad utility in medicinal chemistry and heterocyclic scaffold construction.

Synthesis

  • Route1
    • null|null
      536-90-3
    • ~58%
    • In-stock
      3-Methoxybenzensulfonyl chloride|CS-0034898
      10130-74-2

    References

    • Larkin, Finbar G.; More O'Ferrall, Rory A.; Murphy, Donal G. Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 11 p. 1833 - 1848
  • Route2
    • null|null
      19183-05-2
    • ~43%
    • In-stock
      3-Methoxybenzensulfonyl chloride|CS-0034898
      10130-74-2

    References

    • Corvas International, Inc. Patent: US6342504 B1, 2002 ; Location in patent: Page column 124 ; US 6342504 B1
  • Route3

    References

    • Bahrami, Kiumars; Khodaei, Mohammad M.; Soheilizad, Mehdi Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9287 - 9291

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.6227
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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