Lot numbers can be found on the outside label of a product:
Ethanone, 1-(2-amino-4-thiazolyl)-
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CAS No. 101258-16-6
- Cat. No. CS-0031411
- Purity≥95%
- MDL No.MFCD06090850
*For research and further manufacturing use only, not for direct human use.
Structure of 101258-16-6
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General Information
- CAS No. 101258-16-6
- Cat. No. CS-0031411
- Purity ≥95%
- MDL No. MFCD06090850
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₆N₂OS
- Molecular Weight 142.18
- Synonym(s) 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
- SMILES NC1=NC(C(C)=O)=CS1
Description
1-(2-Aminothiazol-4-yl)ethanone features a reactive thiazole amine moiety paired with a ketone group, enabling direct incorporation into bioconjugation workflows. This bench-stable compound integrates readily into synthetic scaffolds requiring nucleophilic or electrophilic handles, offering high functional group compatibility for medicinal chemistry and probe development.
Application
1-(2-Aminothiazol-4-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the 2-aminothiazole motif into diverse molecular architectures. Its stability under standard synthetic conditions and compatibility with common coupling reactions facilitate efficient access to thiazole-containing scaffolds. The molecule functions as a key intermediate for constructing bioactive heterocycles, particularly in kinase inhibitor and antimicrobial agent development, owing to its predictable reactivity and ease of functionalization.
Synthesis
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Route1
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762271-84-1 - ~57%
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In-stock
101258-16-6
References
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BANYU PHARMACEUTICAL CO., LTD. Patent: EP1598349 A1, 2005 ; Location in patent: Page/Page column 127 ;
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Route2
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116008-78-7 - ~58%
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In-stock
101258-16-6
References
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Chu, Xin-Jie; Fotouhi, Nader; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John; Zhang, Zhuming Patent: US2006/41146 A1, 2006 ; Location in patent: Page/Page column 10 ; US 20060041146 A1
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Route3
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5559-62-6 -
17356-08-0 - ~76%
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In-stock
101258-16-6
References
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Goodnow,, Robert Alan; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John Anthony; Zhang, Zhuming Patent: US2006/63814 A1, 2006 ; Location in patent: Page/Page column 61 ; US 20060063814 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.98
- LogP 0.9279
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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