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CS-W001157 4
Total: USD 88.00

5-Isopropylthiazol-2-amine

  • CAS No. 101080-15-3

  • Cat. No. CS-W007180
  • Molecule weight142.22
  • Purity≥95%
  • MDL No.MFCD13185908

*For research and further manufacturing use only, not for direct human use.

5-Isopropylthiazol-2-amine|CS-W007180

Structure of 101080-15-3

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General Information

  • CAS No. 101080-15-3
  • Cat. No. CS-W007180
  • Purity ≥95%
  • MDL No. MFCD13185908
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀N₂S
  • Molecular Weight 142.22
  • Synonym(s) 5-Isopropyl-thiazol-2-ylaMine
  • SMILES NC1=NC=C(C(C)C)S1

Description

5-Isopropylthiazol-2-amine features a thiazole core with a para-amino group and a sterically hindered isopropyl substituent, delivering enhanced stability and solubility in polar solvents. This scaffold integrates readily into bioactive molecules, serving as a key building block for pharmaceutical intermediates and functionalized heterocycles under standard conditions.

Application

5-Isopropylthiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds. Its functional group tolerance and bench stability facilitate straightforward derivatization via coupling reactions, nucleophilic substitution, and metal-catalyzed transformations. The isopropyl substituent enhances lipophilicity and metabolic stability, supporting its use in optimizing drug-like properties within API development workflows.

Synthesis

  • Route1
    • null|null
      64932-36-1
    • null|null
      17356-08-0
    • ~59%
    • In-stock
      5-Isopropylthiazol-2-amine|CS-W007180
      101080-15-3

    References

    • Helal, Christopher J.; Sanner, Mark A.; Cooper, Christopher B.; Gant, Thomas; Adam, Mavis; Lucas, John C.; Kang, Zhijun; Kupchinsky, Stanley; Ahlijanian, Michael K.; Tate, Bonnie; Menniti, Frank S.; Kelly, Kristin; Peterson, Marcia Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5521 - 5525
  • Route2
    • In-stock
      Isocaproaldehyde|CS-0645781
      1119-16-0
    • null|null
      17356-08-0
    • ~%
    • In-stock
      5-Isopropylthiazol-2-amine|CS-W007180
      101080-15-3

    References

    • ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; HO, David; NALLAN, Laxman; POLAT, Tulay; SUN, Xiaowen; DESAI, Neil Patent: WO2010/144394 A1, 2010 ; Location in patent: Page/Page column 58-59 ; WO 2010/144394 A1
  • Route3
    • null|null
      123-51-3
    • ~%
    • In-stock
      5-Isopropylthiazol-2-amine|CS-W007180
      101080-15-3

    References

    • Kulkarni; Shirsat Journal of Scientific and Industrial Research, 1959 , vol. 18 B, p. 411

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.8487
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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