(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate

Name: (3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1009075-43-7
Cat. No. CS-W021091
Purity≥95%
MDL No.MFCD11111576

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate|CS-W021091

Structure of 1009075-43-7

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Description

This chiral pyrrolidine derivative features a tert-butyl carbamate-protected amine and a fluorine atom at the 4-position, enabling selective incorporation into bioactive molecules. The (3S,4S) stereochemistry ensures high diastereoselectivity in downstream transformations, making it ideal for medicinal chemistry applications requiring precise spatial control.

Application

(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate serves as a key chiral building block in medicinal chemistry, enabling the construction of fluorinated pyrrolidine scaffolds found in bioactive molecules. The protected amine and fluorinated C4 position offer orthogonal reactivity and enhanced metabolic stability. This compound facilitates efficient peptide-like coupling reactions and functions effectively in asymmetric synthesis workflows due to its bench-stable, crystalline nature and favorable purification profile.

General Information

CAS No. 1009075-43-7
Cat. No. CS-W021091
Purity ≥95%
MDL No. MFCD11111576
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₇FN₂O₂
Molecular Weight 204.24
Synonym(s) 1-Pyrrolidinecarboxylicacid, 3-amino-4-fluoro-, 1,1-dimethylethyl ester, (3S,4S)-
SMILES CC(C)(C)OC(=O)N1C[C@H](N)[C@@H](F)C1

Computational Chemistry Data

TPSA 55.56
LogP 0.9025
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2923
Class : 8 (6.1)	Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate

CAS No. 1009075-43-7

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