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CS-W001157 4
Total: USD 88.00

N-(2-Bromo-5-fluorophenyl)acetamide

  • CAS No. 1009-06-9

  • Cat. No. CS-0435053
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-(2-Bromo-5-fluorophenyl)acetamide|CS-0435053

Structure of 1009-06-9

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General Information

  • CAS No. 1009-06-9
  • Cat. No. CS-0435053
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrFNO
  • Molecular Weight 232.05
  • Synonym(s) None
  • SMILES CC(NC1=CC(F)=CC=C1Br)=O

Description

N-(2-Bromo-5-fluorophenyl)acetamide features a brominated and fluorinated aromatic ring paired with an amide-linked acetyl group, enabling direct incorporation into Suzuki-Miyaura and Buchwald-Hartwig coupling cascades. This bench-stable scaffold delivers high functional group tolerance and facilitates rapid access to complex biaryl architectures under standard conditions.

Application

N-(2-Bromo-5-fluorophenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal bromo and amide functionalities. The molecule exhibits excellent bench stability and facilitates efficient functionalization in late-stage diversification. Its fluorinated aryl core supports metabolic stability in bioactive scaffolds, while the acetamide group offers compatibility with standard protecting group strategies and mild deprotection conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.5466
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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