4-Chloro-2-methoxynicotinaldehyde

Name: 4-Chloro-2-methoxynicotinaldehyde
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1008451-58-8
Cat. No. CS-0150526
Purity≥97%
MDL No.MFCD13188720

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-methoxynicotinaldehyde|CS-0150526

Structure of 1008451-58-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1008451-58-8
Cat. No. CS-0150526
Purity ≥97%
MDL No. MFCD13188720
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆ClNO₂
Molecular Weight 171.58
Synonym(s) 4-Chloro-2-methoxypyridine-3-carbaldehyde
SMILES COC1=C(C=O)C(=CC=N1)Cl

Description

4-Chloro-2-methoxynicotinaldehyde is a bench-stable, electron-deficient aldehyde featuring a para-chloro and ortho-methoxy substitution on the pyridine ring. This configuration enhances reactivity in coupling processes while maintaining solubility in common organic solvents. The aldehyde group enables direct incorporation into heterocyclic scaffolds via nucleophilic addition or condensation reactions.

Application

4-Chloro-2-methoxynicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. Its aldehyde functionality facilitates nucleophilic additions and condensation reactions, while the chloro and methoxy groups provide orthogonal sites for further functionalization. The compound exhibits good bench stability and is compatible with standard coupling protocols, facilitating downstream derivatization in API synthesis.

Synthesis

Route1
- 64-17-5
- 140-29-4
- ~%
- In-stock
  
  1008451-58-8
References
- SANOFI; FETT, Eykmar; MOUGENOT, Patrick; NAMANE, Claudie; NICOLAI, Eric; PHILIPPO, Christophe Patent: WO2012/11081 A1, 2012 ; Location in patent: Page/Page column 27 ; WO 2012/011081 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 39.19
LogP 1.5561
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

4-Chloro-2-methoxynicotinaldehyde sigma4-Chloro-2-methoxynicotinaldehyde manufacturer4-Chloro-2-methoxynicotinaldehyde price4-Chloro-2-methoxynicotinaldehyde structure4-Chloro-2-methoxynicotinaldehyde SDSbuy 4-Chloro-2-methoxynicotinaldehyde4-Chloro-2-methoxynicotinaldehyde supplier4-Chloro-2-methoxynicotinaldehyde uses4-Chloro-2-methoxynicotinaldehyde molecular weightprice of 4-Chloro-2-methoxynicotinaldehyde4-Chloro-2-methoxynicotinaldehyde chemical name formula of 4-Chloro-2-methoxynicotinaldehyde

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-2-methoxynicotinaldehyde

CAS No. 1008451-58-8

Recommended Products