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CS-W001157 4
Total: USD 88.00

(6-(Trifluoromethoxy)pyridin-3-yl)boronic acid

  • CAS No. 1008140-70-2

  • Cat. No. CS-W021120
  • Purity≥97%
  • MDL No.MFCD07374890

*For research and further manufacturing use only, not for direct human use.

(6-(Trifluoromethoxy)pyridin-3-yl)boronic acid|CS-W021120

Structure of 1008140-70-2

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General Information

  • CAS No. 1008140-70-2
  • Cat. No. CS-W021120
  • Purity ≥97%
  • MDL No. MFCD07374890
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₃NO₃
  • Molecular Weight 206.92
  • Synonym(s) [6-(TRIFLUOROMETHOXY)PYRIDIN-3-YL]BORONIC ACID
  • SMILES OB(O)C1=CC=C(OC(F)(F)F)N=C1

Description

This trifluoromethoxy-substituted pyridyl boronic acid features enhanced stability and solubility in polar solvents, enabling efficient Suzuki-Miyaura cross-coupling reactions. The electron-deficient pyridine ring facilitates regioselective functionalization, while the boronic acid moiety integrates readily into complex molecular architectures under mild conditions.

Application

(6-(Trifluoromethoxy)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The boronic acid functionality offers reliable reactivity under mild conditions, good bench stability, and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.34
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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