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CS-W001157 4
Total: USD 88.00

Maleimide-DOTA

  • CAS No. 1006711-90-5

  • Cat. No. CS-0127560
  • Purity≥97%
  • MDL No.MFCD32708535
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Maleimide-DOTA|CS-0127560

Structure of 1006711-90-5

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Description

Maleimide-DOTA features a maleimide group conjugated to a DOTA chelator, enabling site-specific bioconjugation via thiol-reactive addition. This bifunctional linker combines the robust metal-binding capacity of DOTA with efficient coupling to cysteine residues, facilitating the creation of stable radiolabeled probes for targeted imaging and theranostic applications under physiological conditions.

Application

Maleimide-DOTA serves as a versatile bifunctional chelator enabling site-specific conjugation to thiol-containing biomolecules via Michael addition, while providing robust metal coordination for radiometals such as Gd³⁺ and Lu³⁺. Its high stability and aqueous compatibility make it ideal for constructing targeted imaging agents and therapeutic conjugates in preclinical development.

General Information

  • CAS No. 1006711-90-5
  • Cat. No. CS-0127560
  • Purity ≥97%
  • MDL No. MFCD32708535
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₃₄N₆O₉
  • Molecular Weight 526.54
  • Synonym(s) Maleimido-mono-amide-DOTA
  • SMILES O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(NCCN2C(C=CC2=O)=O)=O)CC1

Computational Chemistry Data

  • TPSA   191.34
  • LogP   -3.497
  • H_Acceptors   10
  • H_Donors   4
  • Rotatable_Bonds   11

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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