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Structure of 1006711-90-5
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Maleimide-DOTA features a maleimide group conjugated to a DOTA chelator, enabling site-specific bioconjugation via thiol-reactive addition. This bifunctional linker combines the robust metal-binding capacity of DOTA with efficient coupling to cysteine residues, facilitating the creation of stable radiolabeled probes for targeted imaging and theranostic applications under physiological conditions.
Maleimide-DOTA serves as a versatile bifunctional chelator enabling site-specific conjugation to thiol-containing biomolecules via Michael addition, while providing robust metal coordination for radiometals such as Gd³⁺ and Lu³⁺. Its high stability and aqueous compatibility make it ideal for constructing targeted imaging agents and therapeutic conjugates in preclinical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: