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Ethyl 2-(5-fluoropyridin-2-yl)acetate

  • CAS No. 1006686-15-2

  • Cat. No. CS-0439697
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(5-fluoropyridin-2-yl)acetate|CS-0439697

Structure of 1006686-15-2

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General Information

  • CAS No. 1006686-15-2
  • Cat. No. CS-0439697
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀FNO₂
  • Molecular Weight 183.18
  • Synonym(s) ethyl (5-fluoropyridin-2-yl)acetate
  • SMILES CCOC(=O)CC1=NC=C(C=C1)F

Description

Ethyl 2-(5-fluoropyridin-2-yl)acetate features a fluorinated pyridine ring conjugated to an acetoxyethyl ester, enabling efficient integration into heterocyclic synthesis. This bench-stable reagent facilitates C–C bond formation under mild conditions, serving as a key intermediate in pharmaceutical and agrochemical development.

Application

Ethyl 2-(5-fluoropyridin-2-yl)acetate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine C5 position via cross-coupling reactions. The ester group facilitates subsequent transformations such as hydrolysis or reduction, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for constructing bioactive heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H290-H314-H413
Precautionary Statements : P234-P260-P264-P273-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.3263
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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