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CS-W001157 4
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5-Fluoro-6-methylpyridine-2-carboxylic acid

  • CAS No. 1005474-88-3

  • Cat. No. CS-W022384
  • Molecule weight155.13
  • Purity≥97%
  • MDL No.MFCD11040267

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-6-methylpyridine-2-carboxylic acid|CS-W022384

Structure of 1005474-88-3

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General Information

  • CAS No. 1005474-88-3
  • Cat. No. CS-W022384
  • Purity ≥97%
  • MDL No. MFCD11040267
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) 5-Fluoro-6-methylpyridine-2-carboxylicacid
  • SMILES CC1=C(F)C=CC(=N1)C(O)=O

Description

5-Fluoro-6-methylpyridine-2-carboxylic acid features a strategically positioned fluorine atom and methyl group on the pyridine ring, enhancing electron deficiency and metabolic stability. This combination enables direct incorporation into bioactive scaffolds, particularly in kinase inhibitors and pharmaceutical intermediates. The carboxylic acid moiety provides a versatile handle for amide coupling and derivatization under standard conditions.

Application

5-Fluoro-6-methylpyridine-2-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard functional group transformations. Its orthogonal reactivity profile—combining a carboxylic acid for derivatization and strategically positioned fluorine and methyl groups—facilitates efficient late-stage modification in API development. The compound exhibits good bench stability and compatibility with common coupling reactions, supporting scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.22732
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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