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Structure of 54221-93-1
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2,6-Dimethylisonicotinic acid features a pyridine core with methyl groups at the 2 and 6 positions, enhancing steric protection and electronic stability. This configuration imparts improved solubility in organic solvents and resistance to oxidation under standard handling conditions. The carboxylic acid functionality enables direct coupling in peptide synthesis and transition metal catalysis. Its bench-stable nature supports use in iterative reaction sequences without degradation.
2,6-Dimethylisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules. Its ortho-alkylated pyridine core provides enhanced metabolic stability and modulates electronic properties for targeted ligand design. The carboxylic acid functionality facilitates direct amidation, esterification, or coupling reactions, while the methyl groups offer steric protection and improved solubility. Bench-stable and readily purified by recrystallization, it functions efficiently in standard peptide and macrocyclic coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: