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7-Bromo-5-methoxy-2,3-dihydro-1H-inden-1-one

  • CAS No. 1003048-74-5

  • Cat. No. CS-0531953
  • Molecule weight241.08
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-5-methoxy-2,3-dihydro-1H-inden-1-one|CS-0531953

Structure of 1003048-74-5

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General Information

  • CAS No. 1003048-74-5
  • Cat. No. CS-0531953
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrO₂
  • Molecular Weight 241.08
  • Synonym(s) None
  • SMILES O=C1CCC2=C1C(Br)=CC(OC)=C2

Description

7-Bromo-5-methoxy-2,3-dihydro-1H-inden-1-one features a brominated indenone core with a methoxy group at the 5-position, offering enhanced electron-withdrawing character and improved solubility in polar organic solvents. This bench-stable compound integrates readily into transition-metal-catalyzed coupling reactions and serves as a key building block for bioactive heterocycles and functional materials.

Application

7-Bromo-5-methoxy-2,3-dihydro-1H-inden-1-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted indane scaffolds. Its bromine and methoxy functionalities offer orthogonal handles for Suzuki-Miyaura coupling and directed functionalization. The dihydroindanone core provides structural rigidity and favorable pharmacokinetic properties, making it well-suited for the synthesis of bioactive molecules and API intermediates. Bench-stable and readily purified by flash chromatography, it facilitates scalable, high-yielding transformations in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.5866
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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