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CS-W001157 4
Total: USD 88.00

3-(Iodomethyl)oxetane

  • CAS No. 1003013-77-1

  • Cat. No. CS-0045504
  • Purity≥97%
  • MDL No.MFCD18909284

*For research and further manufacturing use only, not for direct human use.

3-(Iodomethyl)oxetane|CS-0045504

Structure of 1003013-77-1

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General Information

  • CAS No. 1003013-77-1
  • Cat. No. CS-0045504
  • Purity ≥97%
  • MDL No. MFCD18909284
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇IO
  • Molecular Weight 198.00
  • Synonym(s) 3-iodomethyl-oxetane
  • SMILES ICC1COC1

Description

3-(Iodomethyl)oxetane is a reactive, bench-stable building block featuring a strained oxetane ring and a terminal iodomethyl group. This combination enables efficient conjugation via nucleophilic substitution or transition-metal-catalyzed coupling reactions. The molecule integrates seamlessly into bioconjugation workflows, offering high functional group tolerance and predictable reactivity under standard conditions.

Application

3-(Iodomethyl)oxetane serves as a versatile, bench-stable building block for the installation of oxetanyl motifs via iodide-mediated cross-coupling. Its reactive iodomethyl group enables efficient Suzuki, Stille, and Negishi couplings under standard conditions, facilitating rapid access to functionalized oxetanes in medicinal chemistry and agrochemical synthesis. The molecule exhibits excellent functional group tolerance and simplifies purification due to its low molecular weight and high reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.0678
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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