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tert-Butyl (3R)-3-(bromomethyl)piperidine-1-carboxylate

  • CAS No. 1002359-91-2

  • Cat. No. CS-0048584
  • Molecule weight278.19
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3R)-3-(bromomethyl)piperidine-1-carboxylate|CS-0048584

Structure of 1002359-91-2

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General Information

  • CAS No. 1002359-91-2
  • Cat. No. CS-0048584
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀BrNO₂
  • Molecular Weight 278.19
  • Synonym(s) tert-butyl (R)-3-(bromomethyl)piperidine-1-carboxylate
  • SMILES CC(C)(C)OC(=O)N1CCC[C@@H](CBr)C1

Description

tert-Butyl (3R)-3-(bromomethyl)piperidine-1-carboxylate delivers a chiral, bench-stable bromomethyl handle at the 3-position of a piperidine ring. This configurationally stable derivative integrates readily into asymmetric synthesis workflows, enabling selective functionalization via nucleophilic substitution. Its steric protection from the tert-butyl group enhances stability during handling and purification.

Application

tert-Butyl (3R)-3-(bromomethyl)piperidine-1-carboxylate serves as a versatile chiral building block for the synthesis of bioactive piperidine derivatives. The bromomethyl group enables efficient nucleophilic substitution reactions, facilitating the installation of diverse side chains under mild conditions. Its tert-butyl carbamate protection offers excellent bench stability and compatibility with a broad range of functional groups, simplifying purification and enabling straightforward deprotection in late-stage synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   3.0284
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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