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3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 1000340-39-5

  • Cat. No. CS-B0488
  • Purity≥97%
  • MDL No.MFCD09880132

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine|CS-B0488

Structure of 1000340-39-5

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General Information

  • CAS No. 1000340-39-5
  • Cat. No. CS-B0488
  • Purity ≥97%
  • MDL No. MFCD09880132
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrClN₂
  • Molecular Weight 231.48
  • Synonym(s) 3-BROMO-4-CHLORO-7-AZAINDOLE
  • SMILES BrC1=CNC2=NC=CC(Cl)=C21

Description

3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine is a heteroaryl building block featuring dual halogen substituents at strategic positions, enabling efficient cross-coupling reactions. The electron-deficient pyrrolo[2,3-b]pyridine core facilitates palladium-catalyzed transformations, while the bromo and chloro groups offer orthogonal reactivity for sequential functionalization. This scaffold integrates readily into pharmaceutical intermediates and advanced materials.

Synthesis

  • Route1

    References

    • SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC. Patent: WO2008/5457 A2, 2008 ; Location in patent: Page/Page column 180 ; WO 2008/005457 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.9788
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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