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CS-W001157 4
Total: USD 88.00

4-Amino-2-chlorobenzamide

  • CAS No. None

  • Cat. No. CS-0118580
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-chlorobenzamide|CS-0118580

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General Information

  • CAS No. None
  • Cat. No. CS-0118580
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O
  • Molecular Weight 170.60
  • Synonym(s) Benzamide,4-amino-2-chloro
  • SMILES O=C(N)C1=CC=C(N)C=C1Cl

Description

4-Amino-2-chlorobenzamide serves as a key intermediate in the synthesis of bioactive heterocycles and pharmaceutical candidates. The molecule features a chlorine atom at the ortho position relative to the amide, enhancing electrophilic reactivity, while the para-amino group provides a handle for further derivatization. This combination enables efficient incorporation into complex scaffolds under mild reaction conditions.

Application

4-Amino-2-chlorobenzamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules. Its ortho-chloro and amino groups offer complementary reactivity for palladium-catalyzed cross-coupling and electrophilic substitution reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative library synthesis and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   69.11
  • LogP   1.0211
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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