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CS-W001157 4
Total: USD 88.00

Diallyl maleate,98% (stabilized with HQ)

  • CAS No. 999-21-3

  • Cat. No. CS-W011724
  • Purity97% (stabilized with HQ)
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Diallyl maleate,98% (stabilized with HQ)|CS-W011724

Structure of 999-21-3

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General Information

  • CAS No. 999-21-3
  • Cat. No. CS-W011724
  • Purity 97% (stabilized with HQ)
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₄
  • Molecular Weight 196.20
  • Synonym(s) Maleic Acid Diallyl Ester (stabilized with HQ); Diallyl maleate
  • SMILES C=CCOC(/C=C\C(OCC=C)=O)=O

Description

tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate is a PROTAC linker featuring a thalidomide analogue, a hydrophilic PEG spacer, and a t-butyl ester. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. Meanwhile, the t-butyl ester can be hydrolyzed to reveal a carboxylic acid for further derivitization.

Synthesis

  • Route1
    • null|null
      106-95-6
    • null|null
      6915-18-0
    • ~84%
    • In-stock
      Diallyl maleate,98% (stabilized with HQ)|CS-W011724
      999-21-3

    References

    • Muthusamy, Sengodagounder; Azhagan, Datshanamoorthy European Journal of Organic Chemistry, 2014 , vol. 2014, # 2 p. 363 - 370
  • Route2
    • null|null
      108-31-6
    • null|null
      106-95-6
    • ~38%
    • In-stock
      Diallyl maleate,98% (stabilized with HQ)|CS-W011724
      999-21-3

    References

    • Akopyan, A. A.; Grigor, S. A.; Torosyan, G. O.; Babayan, A. T. J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 8 p. 1904 - 1906,1776 - 1777
  • Route3
    • null|null
      107-05-1
    • ~%
    • In-stock
      Diallyl maleate,98% (stabilized with HQ)|CS-W011724
      999-21-3

    References

    • US2275467 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H312-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.001
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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