Lot numbers can be found on the outside label of a product:
7-Bromoquinolin-2(1H)-one
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CAS No. 99465-10-8
- Cat. No. CS-W006087
- Purity≥97%
- MDL No.MFCD09743441
*For research and further manufacturing use only, not for direct human use.
Structure of 99465-10-8
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General Information
- CAS No. 99465-10-8
- Cat. No. CS-W006087
- Purity ≥97%
- MDL No. MFCD09743441
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆BrNO
- Molecular Weight 224.05
- Synonym(s) 7-broMoquinolin-2-ol
- SMILES O=C1NC2=C(C=CC(Br)=C2)C=C1
Description
7-Bromoquinolin-2(1H)-one features a bromine substituent at the C7 position of a quinolin-2(1H)-one scaffold, imparting enhanced electrophilicity and facilitating downstream functionalization via cross-coupling reactions. This bench-stable heterocycle serves as a key intermediate in the synthesis of bioactive molecules and advanced materials.
Application
7-Bromoquinolin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via cross-coupling reactions. Its quinolinone core provides a rigid, planar scaffold with favorable solubility and stability for downstream derivatization. The bromo group facilitates palladium-catalyzed transformations, while the lactam functionality offers hydrogen-bonding capacity and enhanced metabolic stability—making it a practical intermediate for targeted synthesis of kinase inhibitors and other bioactive heterocycles.
Synthesis
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Route1
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917341-34-5 - ~%
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In-stock
99465-10-8
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In-stock
99465-09-5
References
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WO2006/134378 A1, ; Page/Page column 61-62 ; WO 2006/134378 A1
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Route2
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In-stock
99455-15-9 - ~%
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In-stock
99465-10-8
References
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WO2008/71961 A1, ; Page/Page column 103-104 ; WO 2008/071961 A1
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Route3
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349426-35-3
- ~%
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In-stock
99465-10-8
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In-stock
99465-09-5
References
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US2011/178041 A1, ; Page/Page column 28 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 32.86
- LogP 2.2906
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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