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CS-W001157 4
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4-(3-Methoxyphenyl)piperidine

  • CAS No. 99329-55-2

  • Cat. No. CS-0462802
  • Molecule weight191.27
  • Purity≥98%
  • MDL No.MFCD05189908

*For research and further manufacturing use only, not for direct human use.

4-(3-Methoxyphenyl)piperidine|CS-0462802

Structure of 99329-55-2

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General Information

  • CAS No. 99329-55-2
  • Cat. No. CS-0462802
  • Purity ≥98%
  • MDL No. MFCD05189908
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO
  • Molecular Weight 191.27
  • Synonym(s) 4-(3-Methoxyphenyl)-piperidine
  • SMILES COC1=CC=CC(=C1)C2CCNCC2

Description

4-(3-Methoxyphenyl)piperidine is a nitrogen-containing heterocycle featuring a methoxy-substituted phenyl ring linked to the piperidine core. This structure imparts enhanced lipophilicity and metabolic stability, enabling effective membrane permeability. The compound serves as a key scaffold in medicinal chemistry for CNS-targeted small molecules, particularly in the development of ligands for dopamine and serotonin receptors.

Application

4-(3-Methoxyphenyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its piperidine core provides favorable solubility and metabolic stability, while the 3-methoxyphenyl group offers orthogonal reactivity for further derivatization. The compound exhibits excellent bench stability and is readily purified by chromatography or recrystallization, making it well-suited for high-throughput synthesis and process development workflows.

Synthesis

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    • In-stock
      4-(3-Methoxyphenyl)piperidine|CS-0462802
      99329-55-2

    References

    • Pasternak, Alexander; Goble, Stephen D.; Vicario, Pasquale P.; Di Salvo, Jerry; Ayala, Julia M.; Struthers, Mary; DeMartino, Julie A.; Mills, Sander G.; Yang, Lihu Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 994 - 998

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.1622
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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