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CS-W001157 4
Total: USD 88.00

6-(Aminomethyl)quinoline

  • CAS No. 99071-54-2

  • Cat. No. CS-W003947
  • Purity≥97%
  • MDL No.MFCD02853688

*For research and further manufacturing use only, not for direct human use.

6-(Aminomethyl)quinoline|CS-W003947

Structure of 99071-54-2

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General Information

  • CAS No. 99071-54-2
  • Cat. No. CS-W003947
  • Purity ≥97%
  • MDL No. MFCD02853688
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂
  • Molecular Weight None
  • Synonym(s) Quinolin-6-ylmethanamine
  • SMILES NCC1=CC(C=CC=N2)=C2C=C1

Description

6-(Aminomethyl)quinoline features a strategically positioned aminomethyl group that enhances solubility and reactivity in synthetic transformations. This nitrogen-rich scaffold serves as a key building block in medicinal chemistry, enabling direct functionalization at the quinoline core. The pendant amine facilitates conjugation and metal coordination, supporting applications in catalyst design and bioconjugation.

Application

6-(Aminomethyl)quinoline serves as a versatile building block in medicinal chemistry, enabling rapid access to biologically active scaffolds through straightforward functional group transformations. Its pendant primary amine facilitates conjugation, amidation, and reductive amination reactions, while the quinoline core provides a rigid, planar framework compatible with diverse heterocyclic extensions. The compound exhibits excellent bench stability and is readily purified by chromatography or recrystallization, making it ideal for high-throughput synthesis and lead optimization workflows.

Synthesis

  • Route1

    References

    • RHIZEN PHARMACEUTICALS SA; INCOZEN THERAPEUTICS PVT. LTD.; VAKKALANKA, Swaroop Kumar Venkata Satya; NAGARATHNAM, Dhanapalan; VISWANADHA, Srikant; MUTHUPPALANIAPPAN, Meyyappan; BABU, Govindarajulu; BHAVAR, Prashant K Patent: WO2013/144737 A2, 2013 ; Location in patent: Paragraph 252 ;
  • Route2
    • null|null
      872047-71-7
    • ~40%
    • In-stock
      6-(Aminomethyl)quinoline|CS-W003947
      99071-54-2

    References

    • NOVARTIS AG; DAI, Miao; FU, Xingnian; HE, Feng; JIANG, Lei; LI, Yue; LIANG, Fang; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YAN, Xiaoxia; YU, Zhengtian; ZHANG, Ji, Yue Patent: WO2011/20861 A1, 2011 ; Location in patent: Page/Page column 60 ;
  • Route3

    References

    • Zhurnal Obshchei Khimii, , vol. 29, p. 1350,1353; engl. Ausg. S. 1325, 1327

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6935
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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