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CS-W001157 4
Total: USD 88.00

4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline

  • CAS No. 99010-64-7

  • Cat. No. CS-0154218
  • Purity≥97%
  • MDL No.MFCD06658174

*For research and further manufacturing use only, not for direct human use.

4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline|CS-0154218

Structure of 99010-64-7

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General Information

  • CAS No. 99010-64-7
  • Cat. No. CS-0154218
  • Purity ≥97%
  • MDL No. MFCD06658174
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄ClN₃
  • Molecular Weight 259.73
  • Synonym(s) 4-Chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline
  • SMILES CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2Cl

Description

Phosphatidylcholine (PC) carries a positively charged quaternary amine and a negatively charged phosphate in its headgroup. It is an important component of mammalian membranes.15:0 PC (1,2-dipentadecanoyl-sn-glycero-3-phosphocholine) may be used:as a component in fluidizing lipid bilayersto study the role of membrane fluidity in mediating membrane sensitivity to small hydrophobic peptides or haptoglobin-related protein (SHP-1)to prepare giant unilamellar lipid vesicles (GUVs)to construct supported phospholipid bilayers to study the gel-fluid phase transition behavior using in situ, temperature-dependent atomic force microscopy

Application

4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline serves as a versatile heterocyclic building block for medicinal chemistry and catalytic transformations. The chloro substituent enables palladium-catalyzed cross-coupling reactions, while the imidazoquinoline core provides structural rigidity and π-system extension. Bench-stable and compatible with standard synthetic workflows, it facilitates the construction of complex scaffolds in drug discovery programs.

Synthesis

  • Route1
    • null|null
      896106-14-2
    • ~74%
    • In-stock
      4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline|CS-0154218
      99010-64-7

    References

    • WO2006/70379 A1, ; Page/Page column 9-10 ;
  • Route2
    • 2-Chloro-N4-isobutylquinoline-3,4-diamine|CS-0607865
      133860-76-1
    • null|null
      122-51-0
    • ~93%
    • In-stock
      4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline|CS-0154218
      99010-64-7

    References

    • US4988815 A1, ;
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   3.8939
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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