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CS-W001157 4
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(R)-5-(Bromomethyl)pyrrolidin-2-one

  • CAS No. 98612-60-3

  • Cat. No. CS-W020693
  • Purity≥97%
  • MDL No.MFCD06799465

*For research and further manufacturing use only, not for direct human use.

(R)-5-(Bromomethyl)pyrrolidin-2-one|CS-W020693

Structure of 98612-60-3

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General Information

  • CAS No. 98612-60-3
  • Cat. No. CS-W020693
  • Purity ≥97%
  • MDL No. MFCD06799465
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈BrNO
  • Molecular Weight 178.03
  • Synonym(s) (R)-5-Bromomethyl-2-pyrrolidinone
  • SMILES O=C1N[C@@H](CBr)CC1

Description

(R)-5-(Bromomethyl)pyrrolidin-2-one features a stereodefined pyrrolidinone core with a reactive bromomethyl handle at the 5-position. This bench-stable, moisture-tolerant reagent integrates readily into synthetic sequences requiring selective alkylation or chain extension. The chiral scaffold supports asymmetric synthesis and enables access to complex nitrogen-containing architectures.

Application

(R)-5-(Bromomethyl)pyrrolidin-2-one serves as a versatile chiral building block for the synthesis of bioactive heterocycles and medicinal chemistry intermediates. The bromomethyl group enables efficient nucleophilic substitution, while the pyrrolidinone scaffold offers excellent functional group tolerance and bench stability. Its stereochemical integrity supports reliable incorporation into complex molecular architectures via standard coupling protocols.

Synthesis

  • Route1

    References

    • Ackermann, Jean; Matthes, Michael; Tamm, Christoph Helvetica Chimica Acta, 1990 , vol. 73, # 1 p. 122 - 132
  • Route2

    References

    • Helvetica Chimica Acta, , vol. 73, # 1 p. 122 - 132
  • Route3

    References

    • Helvetica Chimica Acta, , vol. 73, # 1 p. 122 - 132

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317-H319
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.6599
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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