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CS-W001157 4
Total: USD 88.00

1H-Pyrrolo[2,3-b]pyridin-5-ol

  • CAS No. 98549-88-3

  • Cat. No. CS-D0720
  • Purity≥98%
  • MDL No.MFCD08272242

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[2,3-b]pyridin-5-ol|CS-D0720

Structure of 98549-88-3

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General Information

  • CAS No. 98549-88-3
  • Cat. No. CS-D0720
  • Purity ≥98%
  • MDL No. MFCD08272242
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂O
  • Molecular Weight 134.14
  • Synonym(s) H-PYRROLO[2,3-B]PYRIDIN-5-OL
  • SMILES OC1=CN=C(NC=C2)C2=C1

Description

1H-Pyrrolo[2,3-b]pyridin-5-ol features a fused heterocyclic core combining pyrrole and pyridine motifs, delivering enhanced electronic delocalization and hydrogen-bonding capacity. This scaffold serves as a privileged building block in medicinal chemistry, enabling direct incorporation into bioactive molecules through functionalization at the 5-hydroxyl and nitrogen sites.

Application

1H-Pyrrolo[2,3-b]pyridin-5-ol serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through direct functionalization at the 5-position. Its inherent stability and compatibility with common coupling reactions facilitate efficient derivatization for drug discovery applications. The phenolic hydroxyl group enhances solubility and provides a handle for further modification, while the fused pyrrole-pyridine core offers robust structural rigidity and favorable electronic properties for target engagement.

Synthesis

  • Route1

    References

    • L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
  • Route2

    References

    • EP1154774 B1, ; Page/Page column 113 ;
  • Route3
    • null|null
      111293-48-2
    • ~%
    • In-stock
      1H-Pyrrolo[2,3-b]pyridin-5-ol|CS-D0720
      98549-88-3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 743,746

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.91
  • LogP   1.2685
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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