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CS-W001157 4
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4-Aminopyridine-2-carbonitrile

  • CAS No. 98139-15-2

  • Cat. No. CS-W006522
  • Purity≥98%
  • MDL No.MFCD07374351

*For research and further manufacturing use only, not for direct human use.

4-Aminopyridine-2-carbonitrile|CS-W006522

Structure of 98139-15-2

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General Information

  • CAS No. 98139-15-2
  • Cat. No. CS-W006522
  • Purity ≥98%
  • MDL No. MFCD07374351
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅N₃
  • Molecular Weight 119.12
  • Synonym(s) 4-aminopicolinonitrile
  • SMILES NC1=CC(=NC=C1)C#N

Description

4-Aminopyridine-2-carbonitrile features a pyridine ring bearing an amino group at the 4-position and a nitrile at the 2-position, creating a highly electron-deficient heterocycle. This dual functionality enables efficient coupling in synthetic transformations, particularly in medicinal chemistry scaffolds and functional materials. The compound exhibits good solubility in common organic solvents and stability under standard bench conditions.

Application

4-Aminopyridine-2-carbonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through its dual functionality: the nucleophilic amine and electrophilic nitrile groups. It facilitates efficient derivatization via amidation, cyclization, and transition-metal-catalyzed coupling reactions. The molecule exhibits good bench stability and is compatible with common purification methods, making it a practical choice for iterative synthesis campaigns targeting bioactive compounds.

Synthesis

  • Route1
    • null|null
      557-21-1
    • In-stock
      4-Amino-2-chloropyridine|CS-D1410
      14432-12-3
    • ~19%
    • In-stock
      4-Aminopyridine-2-carbonitrile|CS-W006522
      98139-15-2

    References

    • ABBOTT LABORATORIES Patent: WO2004/76424 A1, 2004 ; Location in patent: Page 131 ; WO 2004/076424 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.7
  • LogP   0.53548
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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