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2-Aminothiazole-4-carbonitrile

  • CAS No. 98027-21-5

  • Cat. No. CS-B1167
  • Molecule weight125.15
  • Purity≥96%
  • MDL No.MFCD00233420

*For research and further manufacturing use only, not for direct human use.

2-Aminothiazole-4-carbonitrile|CS-B1167

Structure of 98027-21-5

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General Information

  • CAS No. 98027-21-5
  • Cat. No. CS-B1167
  • Purity ≥96%
  • MDL No. MFCD00233420
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃N₃S
  • Molecular Weight 125.15
  • Synonym(s) 4-Thiazolecarbonitrile,2-amino-(6CI,9CI)
  • SMILES N#CC1=CSC(N)=N1

Description

2-Aminothiazole-4-carbonitrile features a dual functional group architecture combining an amine and a nitrile at the 2- and 4-positions of the thiazole ring. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds through nucleophilic or coupling reactions. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions.

Application

2-Aminothiazole-4-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-based heterocycles. Its dual functionality—amine and nitrile groups—facilitates diverse transformations, including nucleophilic additions, cyclizations, and coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in multi-step synthesis workflows targeting API scaffolds.

Synthesis

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    • ~%
    • In-stock
      2-Aminothiazole-4-carbonitrile|CS-B1167
      98027-21-5

    References

    • US2007/173506 A1, ; Page/Page column 53 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.7
  • LogP   0.59698
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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