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CS-W001157 4
Total: USD 88.00

5-Bromopicolinonitrile Tedizolid Impurity

  • CAS No. 97483-77-7

  • Cat. No. CS-0214013
  • Purity≥97%
  • MDL No.MFCD00234144

*For research and further manufacturing use only, not for direct human use.

5-Bromopicolinonitrile Tedizolid Impurity|CS-0214013

Structure of 97483-77-7

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General Information

  • CAS No. 97483-77-7
  • Cat. No. CS-0214013
  • Purity ≥97%
  • MDL No. MFCD00234144
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrN₂
  • Molecular Weight 183.01
  • Synonym(s) 5-Bromo-pyridine-2-carbonitrile
  • SMILES N#CC1=NC=C(Br)C=C1

Application

5-Bromopicolinonitrile serves as a key synthetic intermediate in the production of tedizolid, enabling efficient construction of the core heterocyclic scaffold. Its bromo and nitrile functionalities provide orthogonal reactivity for palladium-catalyzed cross-coupling and nucleophilic transformations, facilitating modular derivatization. The compound exhibits good bench stability and compatibility with standard purification techniques, supporting scalable synthesis in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Organic Letters, , vol. 6, # 26 p. 4905 - 4907
  • Route2
    • In-stock
      2,5-Dibromopyridine|CS-W001991
      624-28-2
    • null|null
      773837-37-9
    • ~52%
    • In-stock
      5-Bromopicolinonitrile Tedizolid Impurity|CS-0214013
      97483-77-7

    References

    • LegoChem Biosciences, Inc.; CHO, Young Lag; BAEK, Sung Yoon; CHAE, Sang Eun; KIM, Sun Young; LEE, Hong Bum; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu Patent: EP2692727 A2, 2014 ; Location in patent: Paragraph 0149-0150 ;
  • Route3
    • In-stock
      2,5-Dibromopyridine|CS-W001991
      624-28-2
    • null|null
      544-92-3
    • ~75%
    • In-stock
      5-Bromopicolinonitrile Tedizolid Impurity|CS-0214013
      97483-77-7

    References

    • Ismail, Mohamed A.; Brun, Reto; Easterbrook, Judy D.; Tanious, Farial A.; Wilson, W. David; Boykin, David W. Journal of Medicinal Chemistry, 2003 , vol. 46, # 22 p. 4761 - 4769

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.71578
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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