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CS-W001157 4
Total: USD 88.00

4-Fluoro-2-methoxypyridine

  • CAS No. 96530-81-3

  • Cat. No. CS-W006596
  • Purity≥98%
  • MDL No.MFCD09835267

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-methoxypyridine|CS-W006596

Structure of 96530-81-3

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General Information

  • CAS No. 96530-81-3
  • Cat. No. CS-W006596
  • Purity ≥98%
  • MDL No. MFCD09835267
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight None
  • Synonym(s) pyridine, 4-fluoro-2-methoxy-
  • SMILES COC1=NC=CC(F)=C1

Description

4-Fluoro-2-methoxypyridine is a fluorinated pyridine derivative featuring a methoxy group at the 2-position and a fluoro substituent at the 4-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling efficient coupling reactions and facilitating metabolic stability in bioactive molecules.

Application

4-Fluoro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–F bond and orthogonal reactivity of the methoxy group. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
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      14395-39-2
    • ~%
    • In-stock
      4-Fluoro-2-methoxypyridine|CS-W006596
      96530-81-3

    References

    • Journal of Heterocyclic Chemistry, , vol. 22, # 1 p. 145 - 147
  • Route2

    References

    • Journal of Heterocyclic Chemistry, , vol. 22, # 1 p. 145 - 147
  • Route3
    • In-stock
      4-Amino-2-chloropyridine|CS-D1410
      14432-12-3
    • null|null
      124-41-4
    • ~%
    • In-stock
      4-Fluoro-2-methoxypyridine|CS-W006596
      96530-81-3

    References

    • Synlett, , # 18 p. 2789 - 2791

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.2293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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