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CS-W001157 4
Total: USD 88.00

4-Fluoropyridin-2(1H)-one

  • CAS No. 96530-75-5

  • Cat. No. CS-W018838
  • Purity≥96%
  • MDL No.MFCD07437952

*For research and further manufacturing use only, not for direct human use.

4-Fluoropyridin-2(1H)-one|CS-W018838

Structure of 96530-75-5

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General Information

  • CAS No. 96530-75-5
  • Cat. No. CS-W018838
  • Purity ≥96%
  • MDL No. MFCD07437952
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄FNO
  • Molecular Weight 113.09
  • Synonym(s) 4-Fluoropyridin-2-ol
  • SMILES O=C1C=C(F)C=CN1

Description

4-Fluoropyridin-2(1H)-one features a fluorine atom at the 4-position of a pyridinone scaffold, delivering enhanced electrophilicity and metabolic stability. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling efficient coupling reactions and incorporation into bioactive molecules through its reactive C–H site.

Application

4-Fluoropyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its fluorinated pyridinone core exhibits enhanced metabolic stability and favorable binding interactions in target-directed synthesis. The compound functions as a reliable electrophile in nucleophilic substitution reactions and participates readily in palladium-catalyzed couplings, facilitating rapid access to complex scaffolds. Bench-stable and amenable to purification by standard chromatographic methods, it supports scalable synthesis workflows in drug discovery and process development.

Synthesis

  • Route1

    References

    • Leznoff; Svirskaya; Yedidia Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 145 - 147
  • Route2

    References

    • Journal of Heterocyclic Chemistry, , vol. 22, # 1 p. 145 - 147
  • Route3
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      14395-39-2
    • ~%
    • In-stock
      4-Fluoropyridin-2(1H)-one|CS-W018838
      96530-75-5

    References

    • Journal of Heterocyclic Chemistry, , vol. 22, # 1 p. 145 - 147

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   0.514
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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