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Structure of 958458-89-4
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1-Bromo-2-fluoro-3-iodobenzene features three halogens—bromine, fluorine, and iodine—strategically positioned on the benzene ring, enabling sequential cross-coupling reactions. This trihalogenated scaffold offers precise regiocontrol in Pd-catalyzed transformations, delivering complex substituted arenes with high fidelity under standard conditions.
1-Bromo-2-fluoro-3-iodobenzene serves as a versatile trihalogenated benzene building block for palladium-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity enables sequential functionalization, with bromine and iodine participating in standard Suzuki, Stille, or Negishi couplings while the fluorine remains inert under typical conditions. The compound exhibits excellent bench stability and facilitates the construction of complex substituted arenes and heterocyclic scaffolds relevant to pharmaceutical synthesis.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: