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7-Chloro-1-methyl-1H-pyrazolo[3,4-c]pyridine

  • CAS No. 957760-15-5

  • Cat. No. CS-0040113
  • Molecule weight167.60
  • Purity≥97%
  • MDL No.MFCD09265711

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1-methyl-1H-pyrazolo[3,4-c]pyridine|CS-0040113

Structure of 957760-15-5

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General Information

  • CAS No. 957760-15-5
  • Cat. No. CS-0040113
  • Purity ≥97%
  • MDL No. MFCD09265711
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight 167.60
  • Synonym(s) 7-chloro-1-Methyl-pyrazolo[3,4-c]pyridine
  • SMILES CN1N=CC2=C1C(Cl)=NC=C2

Description

7-Chloro-1-methyl-1H-pyrazolo[3,4-c]pyridine is a heterocyclic scaffold featuring a chlorinated pyrazolopyridine core with enhanced electron-deficient character. This bench-stable compound integrates readily into medicinal chemistry campaigns, serving as a key building block for kinase inhibitors and CNS-targeted therapeutics. Its para-chloro substitution enables selective coupling reactions under standard conditions, facilitating rapid diversification of pharmacophores.

Application

7-Chloro-1-methyl-1H-pyrazolo[3,4-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to kinase inhibitors and CNS-targeted compounds. Its chlorinated pyrazolopyridine core exhibits excellent bench stability, tolerates diverse functional groups, and participates reliably in palladium-catalyzed cross-coupling reactions. The methyl group enhances solubility and metabolic stability, while the electrophilic chlorine facilitates nucleophilic substitution under mild conditions—making it ideal for modular library synthesis and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.6217
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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