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CS-W001157 4
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(2-Bromo-5-(trifluoromethyl)phenyl)boronicacid

  • CAS No. 957034-38-7

  • Cat. No. CS-W020405
  • Purity≥97%
  • MDL No.MFCD09258742

*For research and further manufacturing use only, not for direct human use.

(2-Bromo-5-(trifluoromethyl)phenyl)boronicacid|CS-W020405

Structure of 957034-38-7

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General Information

  • CAS No. 957034-38-7
  • Cat. No. CS-W020405
  • Purity ≥97%
  • MDL No. MFCD09258742
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BBrF₃O₂
  • Molecular Weight 268.82
  • Synonym(s) (2-Bromo-5-(trifluoromethyl)phenyl)boronic acid
  • SMILES FC(F)(F)C1=CC=C(C(B(O)O)=C1)Br

Description

This boronate moiety features a trifluoromethyl group at the para position, enhancing electron deficiency and metabolic stability. The bromine substituent enables efficient palladium-catalyzed cross-coupling reactions under standard conditions. This bench-stable reagent integrates seamlessly into Suzuki-Miyaura coupling workflows for constructing complex aryl scaffolds in medicinal chemistry and materials science.

Application

(2-Bromo-5-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl architectures. Its compatibility with Suzuki-Miyaura coupling conditions facilitates the synthesis of substituted aromatic scaffolds with enhanced metabolic stability. The bromo and trifluoromethyl groups provide orthogonal reactivity for sequential functionalization, while the boronic acid moiety offers excellent bench stability and ease of purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.1477
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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