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(2-(N-Methylsulfamoyl)phenyl)boronic acid

  • CAS No. 956283-09-3

  • Cat. No. CS-0061792
  • Molecule weight215.03
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-(N-Methylsulfamoyl)phenyl)boronic acid|CS-0061792

Structure of 956283-09-3

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General Information

  • CAS No. 956283-09-3
  • Cat. No. CS-0061792
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀BNO₄S
  • Molecular Weight 215.03
  • Synonym(s) (2-[(Methylamino)sulfonyl]phenyl)boronic acid
  • SMILES CNS(=O)(=O)C1=CC=CC=C1B(O)O

Description

This boronic acid features a methylsulfamoyl group at the ortho position, enhancing solubility and metabolic stability. The pendant boronate moiety enables efficient Suzuki-Miyaura cross-coupling under standard conditions, delivering arylated scaffolds with high functional group tolerance.

Application

(2-(N-Methylsulfamoyl)phenyl)boronic acid serves as a versatile boron building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. Its stability in air and moisture facilitates handling and purification, while the sulfonamide group provides enhanced solubility and functional group tolerance. This reagent functions effectively in late-stage diversification and the synthesis of medicinally relevant heterocyclic systems.

Synthesis

  • Route1

    References

    • US2007/259936 A1, ; Page/Page column 182 ; US 20070259936 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   86.63
  • LogP   -1.7255
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   3

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