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CS-W001157 4
Total: USD 88.00

4-(1-Boc-4-piperidyl)phenylboronic acid pinacol ester

  • CAS No. 956136-85-9

  • Cat. No. CS-0061416
  • Molecule weight387.33
  • Purity≥95%
  • MDL No.MFCD16652353

*For research and further manufacturing use only, not for direct human use.

4-(1-Boc-4-piperidyl)phenylboronic acid pinacol ester|CS-0061416

Structure of 956136-85-9

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General Information

  • CAS No. 956136-85-9
  • Cat. No. CS-0061416
  • Purity ≥95%
  • MDL No. MFCD16652353
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₃₄BNO₄
  • Molecular Weight 387.33
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(C2=CC=C(C=C2)B3OC(C)(C)C(O3)(C)C)CC1

Description

tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate features a boronate ester group enabling efficient Suzuki-Miyaura coupling. The tert-butyl piperidine scaffold provides metabolic stability and favorable solubility. This reagent integrates readily into complex molecule synthesis under standard conditions.

Application

tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate serves as a robust boronate building block for Suzuki-Miyaura cross-coupling reactions. The piperidine core provides a versatile scaffold for medicinal chemistry applications, while the tert-butyl carbamate group offers excellent bench stability and ease of deprotection. Functional group tolerance enables efficient late-stage diversification in complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48
  • LogP   3.7102
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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