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CS-W001157 4
Total: USD 88.00

2-(Pyridazin-4-yl)thiazole-4-carboxylic acid

  • CAS No. 955400-58-5

  • Cat. No. CS-0099118
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Pyridazin-4-yl)thiazole-4-carboxylic acid|CS-0099118

Structure of 955400-58-5

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General Information

  • CAS No. 955400-58-5
  • Cat. No. CS-0099118
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅N₃O₂S
  • Molecular Weight 207.21
  • Synonym(s) None
  • SMILES O=C(C1=CSC(C2=CC=NN=C2)=N1)O

Description

This pyridazinyl-thiazole carboxylic acid integrates a rigid heteroaromatic core with a reactive carboxylate handle, enabling direct coupling in peptide and macrocycle synthesis. The electron-deficient pyridazine ring enhances reactivity in nucleophilic substitution, while the thiazole moiety provides metabolic stability and favorable solubility under standard conditions.

Application

2-(Pyridazin-4-yl)thiazole-4-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its pyridazinyl-thiazole scaffold provides enhanced rigidity and polarity, enabling efficient integration into bioactive molecules. The carboxylic acid group facilitates direct derivatization via amide coupling or esterification, while the molecule exhibits good bench stability and solubility in common organic solvents, supporting scalable synthesis and purification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.97
  • LogP   1.2983
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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